Ophiobolin C Phenylalanine irreversible and orally active myeloperoxidase

irreversible and orally active myeloperoxidase (MPO) inhibitor

GSK-269984A displays moderate blood clearance in the ratand dog and high clearance in the monkey which is reflected in the half-life for each species

Smiles: NCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

to less active dihydroxyeicosatrienoic acids and toxic

GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain

Ophiobolin C Phenylalanine irreversible and orally active myeloperoxidaseProduct information CAS Number: 19022 51 6 Molecular Weight: 386. 57 Formula: C25H38O3 Chemical Name: (1R,3S,4R,7S,11S,12R) 4 hydroxy 1,4 dimethyl 12 [(2S) 6 methylhept 5 en 2 yl] 6 oxotricyclo[9. 3. 0. 0,]tetradec 8 ene 8 carbaldehyde Smiles: CC(C)=CCC[C@H](C)[C@H]1CC[C@]2(C)C[C@H]3[C@H](C(=O)C[C@@]3(C)O)C(C=O)=CC[C@H]21 c: 25 InChiKey: PLWMYIADTRHIMY BNFAVABNSA N InChi: InChI=1S C25H38O3 c1 16(2)7 6 8 17(3)19 11 12 24(4)13 21 23(22(27)14