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Kersten WJ
is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring a Bmal1-dLuc luciferase reporter)
3-dihydrobenzofuran-3-yl)acetic acid hydrate
but not vehicle solution (SNL 3D+Veh and SNL 7D+Veh
(2007) Cancer Res
CC-115 - CAS# 1228013-15-7 Catalog No.:M6483-10 Kersten WJCC 115, CAS No. 1228013 15 7, is a dual inhibitor of DNA dependent protein kinase (DNA PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC 115 binds to and inhibits the activity of DNA PK and both raptor mTOR (TOR complex 1 or TORC1) and rictor mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA PK and TOR. DNA PK, a serine threonine kinase and a