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5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]-2
27(17):4007-4010
InChi: InChI=1S/C33H35N7O6/c1-8-28(41)38-24-16-22(12-10-18(24)2)37-33-35-17-23(30(34-4)40-33)32(43)39-25-15-21(11-9-19(25)3)36-31(42)20-13-26(44-5)29(46-7)27(14-20)45-6/h8-17H
8%) are also observed
Formula: C44H69N15O9S
MK-2461 1762 5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]-2MK 2461 is a novel ATP competitive multitargeted inhibitor of activated c Met with a mean IC50 of 2. 5 nM. IC50 value: 2. 5 nM Target: c Metin vitro: MK 2461 inhibits the kinase activity of human c Met with a mean IC50 of 2. 5 nM in the presence of 50 M ATP. Ron (IC50 = 7 nM) and Flt1 (IC50 = 10 nM) are inhibited by MK 2461 with similar potencies to c Met (IC50 = 2. 5 nM), whereas nine other kinases, including FGFR1, FGFR2, FGFR3, PDGFR, KDR, Flt3,
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