LSP-249 hosphocholine Formula: C34H35NO10S

Formula: C34H35NO10S

daily for 11 days in BaF3-BCR-ABL-V299L mediated five weeks old female nu/nu mice models) do not exhibit any apparent general toxicity and do not affect the mouse weight

InChiKey: VMKVDAAFMQKZJS-LFIBNONCSA-N

the gastric cancer cell line MGC803 is exposed to acidified medium (pH 5

4 days) has a tumor:plasma exposure ratio of 12:1 over 24 hours and leads to increased levels of pAkt in tumor tissue

LSP-249 hosphocholine Formula: C34H35NO10SLSP 249 (example 35), extracted from patent WO2016011209A1, is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell. Product information CAS Number: 1801253 04 2 Molecular Weight: 431. 92 Formula: C24H22ClN5O Chemical Name: N [(6 amino 2,4 dimethylpyridin 3 yl)methyl] 2 [(3 chloroquinolin 6 yl)methyl]pyridine 4 carboxamide Smiles: CC1=CC(N)=NC(C)=C1CNC(=O)C1=CC(CC2=CC3=CC(Cl)=CN=C3C=C2)=NC=C1 InChiKey: