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MK-0591 has a high affinity for 5-lipoxygenase activating protein (FLAP) as evidenced by an IC50 value of 1
1056/NEJMe1109971
This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis
BX912 blocks PDK1/Akt signaling in tumor cells and suppresses the anchorage-dependent growth of a variety of tumor cell lines (such as PC-3 cells) in culture or induces apoptosis
Chemical Name: 1-cyclopropyl-6-fluoro-7-[(1S
Labetalone hydrochloride Size:Contact [email protected] for quotation MK-0591 has a high affinityLabetalone hydrochloride (Benzoic amide) is hydrochloride form of labetalone, a blocker of both alpha and beta adrenergic receptors that is used as an antihypertensive. Product information CAS Number: 96441 14 4 Molecular Weight: 362. 85 Formula: C19H23ClN2O3 Chemical Name: 2 hydroxy 5 {2 [(4 phenylbutan 2 yl)amino]acetyl}benzamide hydrochloride Smiles: Cl. CC(CCC1C=CC=CC=1)NCC(=O)C1=CC(C(N)=O)=C(O)C=C1 InChiKey: DJHFVUYXWAEVRA UHFFFAOYSA N InChi:
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