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Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone)
21(11):3990
InChiKey: HCUARRIEZVDMPT-UHFFFAOYSA-N
ZINC3879010
4-tetrahydroquinazolin-4-one hydrochloride
SOS1 PROTAC 9d Size:Contact [email protected] for quotation Cortodoxone is a glucocorticoid steroidThe compound 9d induced SOS1 degradation in various KRAS driven cancer cells and displayed superior antiproliferation activity compared to the agonist itself9d induced the highly cooperative SOS19dVCB complex formation. 9d achieved significant tumor growth inhibition in the xenograft mouse model bearing NCI H358 cells with a good safety profile. These results collectively provide good evidence of using PROTAC 9d to study SOS1 biological functions and
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