SB 242084 Catalog No.:M21140-C Smiles: CN(C)[C@H]1CC2C3=CC(=CC=C3NC=2CC1)NC(=O)C1C=CC(F)=CC=1

Smiles: CN(C)[C@H]1CC2C3=CC(=CC=C3NC=2CC1)NC(=O)C1C=CC(F)=CC=1

InChi: InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3

These sleep effects are also consistent with the pharmacokinetic profile of lorediplon

32-dihydrogenio-1

Chemical Name:  4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1

SB 242084 Catalog No.:M21140-C Smiles: CN(C)[C@H]1CC2C3=CC(=CC=C3NC=2CC1)NC(=O)C1C=CC(F)=CC=1SB 242084 is a 5 HT2C receptor antagonist(pKi=9. 0) that displays 158 and 100 fold selectivity over 5 HT2A and 5 HT2B receptors respectively. IC50 value: 9. 0(pKi) Target: 5 HT2C antagonistin vitro: SB 242084 had over 100 fold selectivity over a range of other 5 HT, dopamine and adrenergic receptors. In studies of 5 HT stimulated phosphatidylinositol hydrolysis using SH SY5Y cells stably expressing the cloned human 5 HT2C receptor, SB 242084 acted as