Really, Isochron Scepter is just broken in blue decks with the amount of 2 mana or less instants at blue's disposal

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For the newer infect creatures, the damage is replaced by poison or -1/-1 counters (depending on what the creature is attacking)
Loxi: It's interesting because it realistically is meant to be a blink payoff based on the colors, but I think this will really find home in some sort of Esper Aristocrats deck like Bane, Lord of Darkness as a way to gain extra value off LTB triggers
That's why you should be sure to pump up this deck by following our Sliver Swarm Upgrade Guide