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1038/ncomms5750
4 nM and 5 nM for PRMT1
35 μg·h/mL)
Formula: C22H23N5O2
GSK0660 differentially regulated 273 transcripts in TNFα-treated cells compared to TNFα alone
BMH-21 - CAS# 896705-16-1 Catalog No.:M7093-2 1038/ncomms5750BMH 21, CAS No. 896705 16 1, is a potent small molecule DNA intercalator. BMH 21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH 21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH 21 effects on the nucleolar stress response were independent of major DNA damage associated PI3 kinase pathways, ATM, ATR and DNA PKcs. BMH 21 is a chemically unique DNA intercalator that has high