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Smiles: CN1CCN(CC2=CC=CC3=C2C=CN3S(=O)(=O)C2=CC=CC=C2Br)CC1
InChi: InChI=1S/C19H24N4O2S/c1-14-13-26-18(20-14)21-17(24)16-8-10-23(11-9-16)19(25)22(2)12-15-6-4-3-5-7-15/h3-7
InChi: InChI=1S/C26H25N5O/c1-17-4-5-18(2)21(12-17)16-31-24-13-20(22-14-28-30(3)15-22)6-7-23(24)29-26(31)25(32)19-8-10-27-11-9-19/h4-15
It is more than 40-fold selective for CDK7 than CDK1
74(6):897-905
AG 556 Catalog No.:M23088-C Smiles: CN1CCN(CC2=CC=CC3=C2C=CN3S(=O)(=O)C2=CC=CC=C2Br)CC1AG 556 is a selective inhibitor of EGFR with IC50 value of 1. 1 M. The epidermal growth factor receptor (EGFR) is the cell surface receptor for epidermal growth factor and plays an important role in tumor invasion and cancer cell proliferation. AG 556 is a selective EGFR inhibitor. In HEK 293 cells expressing KIR2. 3 or Kir2. 1, AG556 (10 M) reversibly reduced KIR2. 3 or Kir2. 1 currents. Also, AG556 inhibited tyrosine phosphorylation of KIR2. 3 or
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