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Mitchell JB
Smiles: CN(C)C(=O)C1=CC2NC(=O)/C(=C(\NC3=CC(CN(C)C)=CC=C3)/C3C=CC=CC=3)/C=2C=C1
Smiles: O=C(NCCCN1C=NC=C1)C1C=C(ON=1)C1=CC=CO1
TAK-960 (2-1000 nM
is a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf
BAY-2416964 - CAS# 2242464-44-2 Catalog No.:M7082-2 Mitchell JBBAY 2416964, CAS No. 2242464 44 2, is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY2416964 specifically binds to AhR, inhibits AhR activation, and prevents AhR mediated signaling. Abrogation of AhR activation prevents the activation of immune tolerant dendritic cells (DCs) and regulatory T cells (Tregs) in the tumor microenvironment (TME). This may
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