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550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection
Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small molecule inhibitors
3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB
110(33):13594-9
21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28
Tivantinib previr 550: a potent and selectiveTivantinib (ARQ 197) is an orally bioavailable small molecule inhibitor of c Met with potential antineoplastic activity. c Met inhibitor ARQ 197 binds to the c Met protein and disrupts c Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c Met protein or expressing consitutively activated c Met protein. c Met protein, the product of the proto oncogene c Met, is a receptor tyrosine kinase also known as