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29)30)3-5-18(20)27(31
In Vitro:mTOR-IN-1 (Compound 12i) inhibits mTOR with a Ki of 1
It is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor
ABT-737 shows great antitumor activity in an ATLL mouse model at a dose of 100 mg/kg
5-triazine hydrochloride
BML-277 nlafaxine 29)30)3-5-18(20)27(31BML 277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML 277 protects T cells from apoptosis by controlling the response of p53 to radiation induced DNA breaks. ML 277 has IC50 = 15 nM; Ki = 37 nM. ML 277 shows 1000 fold greater selectivity for the Chk2 serine threonine kinase than for the Cdk1 B and CK1 kinases (for which IC50 = 12 M and 17 M, respectively). Product information CAS Number: 516480 79 8 Molecular Weight:
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