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TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes
At the mouse H4R
InChi: InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8
before coronary ligation
and 20 µM and ~10-25% inhibition
HPB 67 quarterhydrate TASP0415914 (compound 8j) shows highHPB is a selective inhibitor of HDAC6 deacetylase. Product information CAS Number: 1800066 24 3 Molecular Weight: 328. 36 Formula: C18H20N2O4 Chemical Name: N hydroxy 4 ((N (2 hydroxyethyl) 2 phenylacetamido)methyl)benzamide Smiles: OCCN(CC1C=CC(=CC=1)C(=O)NO)C(=O)CC1C=CC=CC=1 InChiKey: GTFAUKGKYICUDS UHFFFAOYSA N InChi: InChI=1S C18H20N2O4 c21 11 10 20(17(22)12 14 4 2 1 3 5 14)13 15 6 8 16(9 7 15)18(23)19 24 h1 9,21,24H,10 13H2,(H,19,23) Technical