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pro-apoptotic
RO3280 induced apoptosis and cell cycle disorder in leukemia cells
Formula: C24H26ClFN4O
51(11):669-75
Smiles: CC(C)C1CCC(C)CC1C(=O)NCC
Trimetrexate - CAS# 52128-35-5 esthiazolylmethyloxycarbonyl Ritonavir pro-apoptoticTrimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor. It has been used with leucovorin in treating pneumocystis pneumonia. It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport deficient MTX resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. Product information CAS Number: