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RN-1 can abolish long-term memory formation without affecting short-term memory in the novel object recognition (NOR) mouse model
InChiKey: MVOZLTFXYGHZPM-UHFFFAOYSA-N
Deltarasin was used at 5 µM final concentration in various in vitro assays
Hydroxychloroquine (HCQ) was used at 50-100 µM final concentration in various assays
000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases
PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 Catalog No.:M60201-10S RN-1 can abolish long-term memoryPYR 41, CAS No. 418805 02 4, is a ubiquitin activating enzyme inhibitor (UBE1 inhibitor). PYR 41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high MW ubiquitinated proteins. PYR 41 also mediated cross linking of specific protein kinases (Bcr Abl, Jak2) to inhibit their signaling activity. PYR 41 has demonstrated anti tumor activity in animal studies, partially selective protein cross linking may represent an alternate
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