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Smiles: CC1=CN=C(S1)C1C=C(C=C(C=1)OC[C@H]1CN(C)CCO1)C(=O)N[C@H](C)C1=CN=C(N=C1)C(F)(F)F
This prevents EGFR-mediated signaling
4-triazol-1-yl)phosphonic acid
74(5):283-7
22'-tetramethyl-6-(propan-2-yl)-5
AMN082 atalanib Smiles: CC1=CN=C(S1)C1C=C(C=C(C=1)OC[C@H]1CN(C)CCO1)C(=O)N[C@H](C)C1=CN=C(N=C1)C(F)(F)FAMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPS binding (EC50 values, 64 290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects. Product information CAS