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257 and 200 nM in vitro cytotoxicity assay
InChiKey: LLJYFDRQFPQGNY-QINSGFPZSA-N
LDE225 was used at 1 µM final concentration in cellular assays
Formula: C25H31N5O4
2013 Jul 15
TAS-116 - CAS# 1260533-36-5 Catalog No.:M6713-10 257 and 200 nM inTAS 116, CAS No. 1260533 36 5, also known as Pimitespib, is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo radiosensitizing activities. TAS 116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent signaling, induces apoptosis, and
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