AT7867 dihydrochloride Catalog No.:M9924-2 Smiles: CCOC1C=CC(CC2=CC(=CC=C2Cl)[C@@]23O[C@](CO2)(CO)[C@@H](O)[C@H](O)[C@H]3O)=CC=1

Smiles: CCOC1C=CC(CC2=CC(=CC=C2Cl)[C@@]23O[C@](CO2)(CO)[C@@H](O)[C@H](O)[C@H]3O)=CC=1

S-(+)-Rolipram suppresses LPS-induced TNFα expression from human monocyte through inhibiting PDE4 with IC50 about 2 μM

Rabindran SK

L'Allier PL

is an autophagy inhibitor

AT7867 dihydrochloride Catalog No.:M9924-2 Smiles: CCOC1C=CC(CC2=CC(=CC=C2Cl)[C@@]23O[C@](CO2)(CO)[C@@H](O)[C@H](O)[C@H]3O)=CC=1AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. This ATP competitive small molecule potently inhibits both AKT and p70S6K activity at the cellular level, as measured by inhibition of GSK3beta and S6 ribosomal protein phosphorylation, and also causes growth inhibition in a range of human cancer cell lines as a single agent. Product information CAS Number: 1431697 86 7