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Tegatrabetan (BC2059) is an antagonist of β-Catenin
Ba/F3-TEL-TRKC (IC50 of 3
PMID: 31927622
Its main effects are dilation of the arteries supplying blood to the legs and decreasing platelet coagulation
Cancer Cell
RAF265 enafil dihydrochloride Tegatrabetan (BC2059) is an antagonistCHIR 265 is an orally bioavailable small molecule with potential antineoplastic activity. CHIR 265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR 2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras Raf MEK ERK signaling pathway and are frequently
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