PROTAC ERRα Degrader-3 616ROTAC EED degrader-1 Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC[C@H](N)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)[C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)NCC(N)=O

Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC[C@H](N)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)[C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)NCC(N)=O

[Epub ahead of print] PubMed PMID: 25260842

168(3):632-43

Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation

both regulated by NF-kappaB activation

PROTAC ERRα Degrader-3 616ROTAC EED degrader-1 Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC[C@H](N)C(=O)N[C@@H](CC2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)[C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)NCC(N)=OPROTAC ERR Degrader 3 is a potent and selective ERR degrader based on PROTAC. PROTAC ERR Degrader 3 is capable of specifically degrading ERR protein by >80% at a concentration of 30 nM. PROTAC ERR Degrader 3 is inactive against ERR and ERR proteins. Product information CAS Number: 2306388 65 6 Molecular Weight: 956. 99 Formula: C47H50F6N6O7S Chemical Name: (2S, 4R) 1 [(2S) 2 {5 [(2E) 3 (4 {[2, 4 bis(trifluoromethyl)phenyl]methoxy} 3 methoxyphenyl) 2