EL-102 islignan Smiles: NC(N)=NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2C=CC=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

Smiles: NC(N)=NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2C=CC=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25

In xenograft models of acute myeloid leukemia and multiple myeloma

and Lassa viruses

CAS Number: 547-65-9

EL-102 islignan Smiles: NC(N)=NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2C=CC=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=OEL102 is a inhibitor of HIF1 , Which can inhibit tubulin polymerisation and decreased microtubule stability. target: HIF1IC 5020 40 nM. in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI stained cells cultured for 24, 48 and 72 h, following treatment. EL102 induces apoptosis and causes G2 M arrest, preventing the cell from entering into mitosis. In vivo: CWR22 tumours were taken from