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PubMed PMID: 11258879
CC1ON=C(C=1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C([O-])=O)N2C1=O)C1=CC=CC=C1Cl
InChiKey: FXKSEJFHKVNEFI-GCZBSULCSA-N
2012 Oct 25
also known as Rupatadine
Geldanamycin 0565 PubMed PMID: 11258879Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and inhibits its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. Hsp90 geldanamycin complex. PDB 1yet Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v Src, Bcr Abl and p53 preferentially over their normal
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