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is a small molecule inhibitor of polycomb repressive complex 1
Welling DB
CAS Number: 2370997-94-5
Churakov AV
Gauglitz GG
AMD-070 Catalog No.:M10820-10 is a small molecule inhibitorMavorixafor, also known as AMD11070, AMD070, X4P 001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF 1 ligand binding (IC50 = 12. 5 1. 3 nM), inhibits SDF 1 mediated calcium flux (IC50 = 9. 0 2. 0 nM) and SDF 1 mediated activation of the CXCR4 receptor as measured by a Eu GTP binding assay (IC50 =39. 8 2. 5 nM) or a [(35)S] GTPS binding assay (IC50 =19. 0 4. 1 nM), and inhibits SDF 1 stimulated chemotaxis (IC50
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