A-740003 n L-pyroglutamic Acid Smiles: CN(C1C=CC(=CC=1)NC(=O)NC1C=CC(=CC=1)OC(F)(F)F)C1=CC=NC(NC2C=C(C=CC=2)S(N)(=O)=O)=N1

Smiles: CN(C1C=CC(=CC=1)NC(=O)NC1C=CC(=CC=1)OC(F)(F)F)C1=CC=NC(NC2C=C(C=CC=2)S(N)(=O)=O)=N1

is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50 ~ 0

InChiKey: HEAIGWIZTYAQTC-UHFFFAOYSA-N

which are inhibited with IC50s in the range of 2 to 3 μM

2009 Aug 20

A-740003 n L-pyroglutamic Acid Smiles: CN(C1C=CC(=CC=1)NC(=O)NC1C=CC(=CC=1)OC(F)(F)F)C1=CC=NC(NC2C=C(C=CC=2)S(N)(=O)=O)=N1A 740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A 740003 potently blocks agonist evoked IL 1 release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP 1 cells. Product information CAS Number: 861393 28 4 Molecular Weight: 474. 55 Formula: C26H30N6O3 Synonym: A 740003 A740003 Chemical Name: N [1 [[(Cyanoamino)(5