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Molecular Weight: 333
in complex with the cytosolic protein FK-binding protein 12 (FKBP12)
a cholesteryl ester transfer protein inhibitor
93 mL/min/kg
LDN-214117 demonstrates selective inhibition of ALK2 and ALK1 in preference to ALK3 kinase activity
TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 Molecular Weight: 333TAK 243 (MLN7243), CAS No. 1450833 55 2, is a potent, selective and cell permeable small molecule inhibitor of the ubiquitin activating enzyme (UAE) at nM range. The ubiquitin activating enzymes, found more active in cancer cells than in normal healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via proteasome. TAK 243 treatment caused depletion of cellular ubiquitin conjugates, resulting in
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