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BMS-345541 (10 μM) inhibits growth of Normal human epidermal melanocytes
The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation
and cell-permeable protein kinase C inhibitor
Crew et al (2018) Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1
Not for human use
AG-014699(PF-01367338) oc Malate BMS-345541 (10 μM) inhibits growthRucaparib (AG014699) is an orally active and potent inhibitor of PARP with Ki of 1. 4 nM for PARP1 in a cell free assay. Rucaparib shows binding affinity to eight other PARP domains. Product information CAS Number: 283173 50 2 Molecular Weight: 323. 36 Formula: C19H18FN3O Synonym: AG 14699 AG014447 (as free base) PF 01367338 Rucaparib free base Rubraca Related CAS Number: 459868 92 9 (Rucaparib phosphate) 1859053 21 6 (Rucaparib Camsylate) Chemical
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