BIIB021 D5 Leflunomide prevents the expansion of

Leflunomide prevents the expansion of activated and autoimmune lymphocytes by interfering with the cell cycle progression due to inadequate production of rUMP and utilizing mechanisms involving p53

every 24 hours

mg/kg once per day to impair tumor growth in an SW480 colon carcinoma xenograft model

CAS Number: 446-72-0

Chemical Name: 4-((5-amino-1-(2

BIIB021 D5 Leflunomide prevents the expansion ofBIIB021, also known as CNF2024, is an orally active, purine scaffold, small molecule inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90 inhibitor CNF2024 specifically blocks active HSP90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this may result in the inhibition of cellular proliferation in susceptible tumor