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CNCCN(C)C1=CC(OC)=C(C=C1NC(=O)C=C)NC1N=C(C=CN=1)C1=CN(C)C2C=CC=CC1=2
PD 168568 dihydrochloride has ability to inhibit amphetamine stimulated locomotor activity in the rat
Chemical Name: 3-[3-(difluoromethyl)-1
14-hexaen-4-ol
K J Murray
RORγt Inverse agonist 8 gonist P550 (mouse rat) CNCCN(C)C1=CC(OC)=C(C=C1NC(=O)C=C)NC1N=C(C=CN=1)C1=CN(C)C2C=CC=CC1=2RORt Inverse agonist 8 is a potent, selective, orally bioavailable RORt inverse agonist, with an IC50 of 19 nM for human RORt LBD. Product information CAS Number: 2079892 79 6 Molecular Weight: 475. 59 Formula: C26H33N7O2 Chemical Name: N (8 {[(3S) 4 cyclopentanecarbonyl 3 methylpiperazin 1 yl]methyl} 7 methylimidazo[1,2 a]pyridin 6 yl) 2 methylpyrimidine 5 carboxamide Smiles: C[C@H]1CN(CC2C3=NC=CN3C=C(NC(=O)C3=CN=C(C)N=C3)C=2C)CCN1C(=O)C1CCCC1