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female nude mice) treatment shows a significant suppression of tumor growth
Formula: C6H15ClF2N2O3
Protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins[2]
at or below the maximum tolerated dose
Solubility: DMSO : ≥ 100 mg/mL (68
Asenapine 0289 female nude mice) treatment showsAsenapine, also known as Org 5222 and HSDB 8061, shows high affinity (pKi) for numerous receptors, including the serotonin 5 HT1A (8. 6), 5 HT1B (8. 4), 5 HT2A (10. 2), 5 HT2B (9. 8), 5 HT2C (10. 5), 5 HT5A (8. 8), 5 HT6 (9. 5), and 5 HT7 (9. 9) receptors, the adrenergic 1 (8. 9), 2A (8. 9), 2B (9. 5), and 2C (8. 9) receptors, the dopamine D1 (8. 9), D2 (8. 9), D3 (9. 4), and D4 (9. 0) receptors, and the histamine H1 (9. 0) and H2 (8. 2) receptors.
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