MLN8237 (Alisertib) - Aurora A inhibitor. CAS# 1028486-01-2 60125 The nuclear receptors REV-ERB-α and

The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins

InChiKey: YHHFKWKMXWRVTJ-OQKWZONESA-N

Chem Pharm Bull (Tokyo)

Gonzalez R

Gardell LR

MLN8237 (Alisertib) - Aurora A inhibitor. CAS# 1028486-01-2 60125 The nuclear receptors REV-ERB-α andMLN8237 (Alisertib), CAS No. 1028486 01 2, is a highly potent and selective Aurora A inhibitor with an IC50 of 1. 2 nM, >200 fold selective towards structurally related Aurora B (IC50 of 396. 5 nM). It does not have any significant activity against 205 other kinases. MLN8237 treatment inhibits the phosphorylation of Aurora A in MM1. S and OPM1 cells, without affecting the Aurora B mediated histone H3 phosphorylation. MLN8237 significantly inhibits