HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S 347174-05-4

347174-05-4

is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM

3(2H)-dione

3)-dioxygenase) pathway inhibitor with Ki ~7 nM (EC50 ~75 nM) in vitro and in cell based assays

It sensitized chemotherapy-resistant ovarian cancer cell lines to paclitaxel

HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S 347174-05-4HIF C2, CAS No. 1422955 31 4, is a potent and selective allosteric inhibitor of hypoxia inducible factor 2 (HIF 2). It binds within the internal cavity of HIF 2 PAS B (Kd of 81 nM) and disrupts heterodimerization of the full length HIF 2 transcription factor. HIF C2 functions effectively as a HIF 2 inhibitor in living cells, disrupting HIF 2 DNA binding and inhibiting the transcription of its target genes. Moreover, HIF C2 is selective for the HIF 2