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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
PubMed PMID: 22574676
Formula: C24H26BrN3O3
CAS Number: 64-86-8
Smiles: O=C(NC1=CC=CC2=C1OC(=CC2=O)C1NN=NN=1)C1C=CC(=CC=1)OCCCCC1C=CC=CC=1
BMS-927711 asvir diacetone Activation of the pseudokinase MLKLRimegepant, also known as BMS 927711 and BHV 3000, is a potent, selective, competitive, and orally active calcitonin gene related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS 927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile. Product information CAS Number: 1289023 67 1
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