Linerixibat tiglinide Calcium Smiles: COC1C2OC(=O)C3C=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(OC)=C4OC(=O)C(=CC=1O)C=2C4=3

Smiles: COC1C2OC(=O)C3C=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(OC)=C4OC(=O)C(=CC=1O)C=2C4=3

NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen)

Hydroxytyrosol (3

Smiles: CC(C)(C)C[C@@H]1N[C@H]([C@H](C2=CC=CC(Cl)=C2F)[C@@]1(C#N)C1=CC=C(Cl)C=C1F)C(=O)NC1=CC=C(C=C1OC)C(O)=O

increases MIN6 insulin secretion (26-fold

Linerixibat tiglinide Calcium Smiles: COC1C2OC(=O)C3C=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(OC)=C4OC(=O)C(=CC=1O)C=2C4=3Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium dependent bile acid transporter (ASBT) inhibitor with an IC50 of 42 nM human ASBT. Linerixibat can be used as lipid lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment. Product information CAS Number: 1345982 69 5 Molecular Weight: 546. 68 Formula: C28H38N2O7S Chemical Name: 3 ({[(3R,5R) 3 butyl 3 ethyl 7