Fezolinetant HCl Size:10 mg solid Pretreatment of adipocytes with GF-109203X

Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates

CAS Number: 116649-85-5

and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices

4-tetramethylcyclobutoxy]benzonitrile

50(2):355-67

Fezolinetant HCl Size:10 mg solid Pretreatment of adipocytes with GF-109203XFezolinetant, also known as ESN 364, is Neurokinin 3 (NK 3) receptor antagonist which has been optimized for use in womens health, and is being developed for sex hormone related disorders such as endometriosis, polycystic ovarian syndrome and uterine fibroids. Fexolinetant allows modulation of the hypothalamic pituitary gonadal axis with a selective action on hormones relevant to disease. The agent is expected to have greater tolerability than