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Transpl Immunol
It also inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2C19 (IC50s = 13 and 8 μM
4(12):e8104
7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-benzamide
compared to CDK2 (IC50=0
BLU-9931 - CAS# 1538604-68-0 255 Transpl ImmunolBLU 9931, CAS No. 1538604 68 0, is a potent and irreversible small molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU 9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU 9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor
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