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selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM
PF-04217903 displays >1000-fold selectivity for c-Met over a panel of 208 kinases
Di Antonio M
BGT226 induced autophagy as indicated by the aggregation and upregulation of the microtubule-associated protein light chain 3B-II
resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation
Tolvaptan nhibitor II selective and cell permeable BRPF1Tolvaptan is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U. S. Food and Drug Administration (FDA) on May 19, 2009. Product information CAS Number: 150683 30 0 Molecular Weight: 448. 94 Formula: C26H25ClN2O3 Chemical Name: N [4 (7 chloro 5
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