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InChiKey: JMPFSEBWVLAJKM-UHFFFAOYSA-N
As with other sulfonamides
which inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50 of 50 nM
CAS Number: 881681-01-2
PubMed PMID: 25241015
Tozasertib - CAS# 639089-54-6 Size:Solid 2 mg InChiKey: JMPFSEBWVLAJKM-UHFFFAOYSA-NTozasertib, also known as VX 680, MK0457 or VE465, is a synthetic, small molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis. Product information
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