You don't need to keep all of your draw cards in your opening hand, but try to have a strategy for obtaining extra cards built into your opening
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Most of the deck consists of creatures, and you will be flooding the battlefield with great creatures by casting multiple a turn with web-slinging
If an expertise spell allows you to cast a split card, you may cast either half or, if that split card has fuse, both halves.
However, boxes of the set are still over $400, thus showing the problematic nature of the current scalper's market for the game