CPI-444 - CAS# 1202402-40-1 0101 so it has IC50 >1

so it has IC50 >1 µM for inhibiting demthylation of H3K4 in U2OS human osteosarcoma cell line and in human breast adenocarcinoma MCF7 tumor cell proliferation assay

Assessment of the protective effect of KN-93 drug in systemic epilepsy disorders induced by pilocarpine in male rat

1-dimethylethyl ester

ISRIB blocks multiple stress effectors

10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11

CPI-444 - CAS# 1202402-40-1 0101 so it has IC50 >1CPI 444, CAS No. 1202402 40 1, is an orally administered antagonist of the adenosine A2A receptor. Upon oral administration, CPI 444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine induced